583 research outputs found
Mars Science Laboratory Workstation Test Set
The Mars Science Laboratory developed the Workstation TestSet (WSTS) is a computer program that enables flight software development on virtual MSL avionics. The WSTS is the non-real-time flight avionics simulator that is designed to be completely software-based and run on a workstation class Linux PC
The Student Movement Volume 105 Issue 9: Special Edition AUSA Elections
PRESIDENT
Dongchan Kim
EXECUTIVE VICE PRESIDENT
Andrew Rappette
T Bruggemann
Torrey Joo
SOCIAL VICE PRESIDENT
Taylor Biek
STUDENT MOVEMENT EDITOR
Alyssa Henriquez
SENATOR-AT-LARGE
Abraham Bravo
Karenna Lee
LAST WORD
Who Cares What He Wears?: Doug Emhoff\u27s Debt to Second Ladies, Alyssa Henriquezhttps://digitalcommons.andrews.edu/sm-105/1011/thumbnail.jp
A phase 3 multicenter, prospective, open-label efficacy and safety study of immune globulin (human) 10% caprylate/chromatography purified in patients with myasthenia gravis exacerbations
Background: Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular transmission. Exacerbations may involve increasing bulbar weakness and/or sudden respiratory failure, both of which can be critically disabling. Management of MG exacerbations includes plasma exchange and intravenous immunoglobulin (IVIG); they are equally effective, but patients experience fewer side effects with IVIG. The objective of this study was to assess the efficacy and safety of immune globulin caprylate/chromatography purified (IGIV-C) in subjects with MG exacerbations. Methods: This prospective, open-label, non-controlled 28-day clinical trial was conducted in adults with MG Foundation of America class IVb or V status. Subjects received IGIV-C 2 g/kg over 2 consecutive days (1 g/kg/day) and were assessed for efficacy/safety on Days 7, 14, 21, and 28. The primary efficacy endpoint was the change from Baseline in quantitative MG (QMG) score to Day 14. Secondary endpoints of clinical response, Baseline to Day 14, included at least a 3-point decrease in QMG and MG Composite and a 2-point decrease in MG-activities of daily living (MG-ADL). Results: Forty-nine subjects enrolled. The change in QMG score at Day 14 was significant (p < 0.001) in the Evaluable (-6.4, n = 43) and Safety (-6.7, n = 49) populations. Among evaluable subjects, Day 14 response rates were 77, 86, and 88% for QMG, MG Composite, and MG-ADL, respectively. IGIV-C showed good tolerability with no serious adverse events. Conclusions: The results of this study show that IGIV-C was effective, safe, and well tolerated in the treatment of MG exacerbations
The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis
Diabetic vascular complications are associated with impaired ischaemia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis. microRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. The role of miRNAs in the rescue of diabetes-impaired angiogenesis by rHDL is unknown. Using a miRNA array, we found that rHDL inhibits hsa-miR-181c-5p expression in vitro and using a hsa-miR-181c-5p mimic and antimiR identify a novel anti-angiogenic role for miR-181c-5p. miRNA expression was tracked over time post-hindlimb ischaemic induction in diabetic mice. Early post-ischaemia when angiogenesis is important, rHDL suppressed hindlimb mmu-miR-181c-5p. mmu-miR-181c-5p was not detected in the plasma or within HDL, suggesting rHDL specifically targets mmu-miR-181c-5p at the ischaemic site. Three known angiogenic miRNAs (mmu-miR-223-3p, mmu-miR-27b-3p, mmu-miR-92a-3p) were elevated in the HDL fraction of diabetic rHDL-infused mice early post-ischaemia. This was accompanied by a decrease in plasma levels. Only mmu-miR-223-3p levels were elevated in the hindlimb 3 days post-ischaemia, indicating that rHDL regulates mmu-miR-223-3p in a time-dependent and site-specific manner. The early regulation of miRNAs, particularly miR-181c-5p, may underpin the rescue of diabetes-impaired angiogenesis by rHDL and has implications for the treatment of diabetes-related vascular complications
Towards an optimal treatment algorithm for metastatic pancreatic ductal adenocarcinoma (PDA)
Chemotherapy remains the mainstay of treatment for advanced pancreatic ductal adenocarcinoma (pda). Two randomized trials have demonstrated superiority of the combination regimens folfirinox (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) and gemcitabine plus nab-paclitaxel over gemcitabine monotherapy as a first-line treatment in adequately fit subjects. Selected pda patients progressing to first-line therapy can receive secondline treatment with moderate clinical benefit. Nevertheless, the optimal algorithm and the role of combination therapy in second-line are still unclear. Published second-line pda clinical trials enrolled patients progressing to gemcitabine-based therapies in use before the approval of nab-paclitaxel and folfirinox. The evolving scenario in second-line may affect the choice of the first-line treatment. For example, nanoliposomal irinotecan plus 5-fluouracil and leucovorin is a novel second-line option which will be suitable only for patients progressing to gemcitabinebased therapy. Therefore, clinical judgement and appropriate patient selection remain key elements in treatment decision. In this review, we aim to illustrate currently available options and define a possible algorithm to guide treatment choice. Future clinical trials taking into account sequential treatment as a new paradigm in pda will help define a standard algorithm
Cooperation in Microbial Populations: Theory and Experimental Model Systems
Cooperative behavior, the costly provision of benefits to others, is common
across all domains of life. This review article discusses cooperative behavior
in the microbial world, mediated by the exchange of extracellular products
called public goods. We focus on model species for which the production of a
public good and the related growth disadvantage for the producing cells are
well described. To unveil the biological and ecological factors promoting the
emergence and stability of cooperative traits we take an interdisciplinary
perspective and review insights gained from both mathematical models and
well-controlled experimental model systems. Ecologically, we include crucial
aspects of the microbial life cycle into our analysis and particularly consider
population structures where an ensemble of local communities (sub populations)
continuously emerge, grow, and disappear again. Biologically, we explicitly
consider the synthesis and regulation of public good production. The discussion
of the theoretical approaches includes general evolutionary concepts,
population dynamics, and evolutionary game theory. As a specific but generic
biological example we consider populations of Pseudomonas putida and its
regulation and utilization of pyoverdines, iron scavenging molecules. The
review closes with an overview on cooperation in spatially extended systems and
also provides a critical assessment of the insights gained from the
experimental and theoretical studies discussed. Current challenges and
important new research opportunities are discussed, including the biochemical
regulation of public goods, more realistic ecological scenarios resembling
native environments, cell to cell signalling, and multi-species communities.Comment: Review article, 88 pages, 14 figure
Brazilian spring wheat germplasm as source of genetic variability.
As part of a Canada-Brazil germplasm exchange, 106 modern and ancient Brazilian spring wheat cultivars have been genotyped and phenotypically evaluated in Canada since 201
The Student Movement Volume 106 Issue 8: Cardinals Cheer, Thanksgiving is Here!
HUMANS
Meet Your 2021-2022 AU Cardinals Men\u27s Basketball Team, Interviewed by: Timmy Duado
What Are You Thankful For?, Interviewed by: Grace No
Meet Your 2021-2022 AU Cardinals Women\u27s Basketball Team, Interviewed by: Taylor Uphus
ARTS & ENTERTAINMENT
Thanksgiving Film Recommendations!, Megan Napod
The Harder They Fall , Hannah Cruse
What is CATHARSIS?, Solana Campbell
NEWS
Andrews Autumn Conference on Science & Religion, Abigail Lee
AUSA Hosts Open Gym, Karenna Lee
Campus Concert Crawl, Abigail Lee
IDEAS
Hidden out of Season, Evin-Nazya Musgrove
Risk and Reward in Squid Game , Yoel Kim
The Necessity of Firearm Safety Education, Nathan Cheng
PULSE
Honors Testimony: Worship in the Church, Honors Student
Productivity... (and Pronouns ), T Bruggemann
Thanksgiving Traditions of Your Student Movement Editors, Alannah Tjhatra
THE LAST WORD
Thanksgiving Dinner and Communion, Alyssa Henriquezhttps://digitalcommons.andrews.edu/sm-106/1007/thumbnail.jp
Centrality dependence of the expansion dynamics in Pb-Pb collisions at 158 A GeV/c
Two-particle correlation functions of negatively charged hadrons from Pb-Pb
collisions at 158 GeV/c per nucleon have been measured by the WA97 experiment
at the CERN SPS. A Coulomb correction procedure that assumes an expanding
source has been implemented. Within the framework of an expanding thermalized
source model the size and dynamical state of the collision fireball at
freeze-out have been reconstructed as a function of the centrality of the
collision. Less central collisions exhibit a different dynamics than central
ones: both transverse and longitudinal expansion velocities are slower, the
expansion duration is shorter and the system freezes out showing smaller
dimensions and higher temperature.Comment: 22 pages, 11 figures, Te
The Student Movement Volume 106 Issue 1: Capping Off AU\u27s Fifth Change Day
HUMANS
Freshman Spotlight: Abby Shim (freshman, business), Interviewed by: Lauren Kim
Interview with Change Day Coordinator Teela Ruehle, Interviewed by: Karenna Lee
My Goals This Year Are..., Gloria Oh
ARTS & ENTERTAINMENT
Shang-Chi: Run, Don\u27t Walk to Your Closest Theater, Solana Campbel
Shadow and Bone: A Book and TV Show Review, Kaela McFadden
What Are You Listening To?, Steven Injety
NEWS
COVID Regulations on Campus: Part 2.5, Yoel Kim
Students Get Wrapped Up In Change Day Christmas Event, Nathan Mathieu
The Gazebo Closure, Brendan Syto
IDEAS
In the Archives: AU During 9/11, Lyle Goulbourne
Lily Pads and Epidemics, Alexander Navarro
Quality Time, Chase Wilder
PULSE
5 Ways To Make Your Studying Better, T Bruggeman
Adventures Around Andrews (Biking Distance), Gloria Oh
Back to Andrews, Izzy Koh
THE LAST WORD
Offline Anxiety, Alyssa Henriquezhttps://digitalcommons.andrews.edu/sm-106/1000/thumbnail.jp
- …